![]() However, mango-cashew nut cross-sensitisation seems to be of less clinical relevance as only few cases have been reported of mango allergic individuals co-sensitised to pistachio or cashew apple fruit. Mango has shown to be an important cross-reacting food for patients suffering from the “celery-mugwort-spice syndrome” and “latex-fruit syndrome”, partly caused by the Bet v 1 and 2-like type allergens. Recent case reports describing the incidence of cashew nut-allergic patients experiencing anaphylaxis after consumption of pink peppercorn or sumac emphasise the potential risk of cross-reactivity among different members of the Anacardiaceae family. Mango, pink peppercorn (often included in peppercorn blends and seasoning mixes), and the Middle Eastern spice sumac are also phylogenetically classified as Anacardiaceae. ![]() The strong phylogenetic relationship between cashew and pistachio nut is reflected by the high amino acid similarity and conserved three-dimensional regions between the cashew nut and pistachio seed storage allergens Ana o 1/Pis v 3 (7S vicilin), Ana o 2/Pis v 2 (11S legumin), and Ana o 3/Pis v 1 (2S albumin) with a similarity of 78, 80, and 70%, respectively. ![]() Amongst Anacardiaceae members, allergic cross-reactivity between pistachio and cashew nut is well recognised and avoidance of both nuts is advised in case of a confirmed cashew nut allergy. Photos are from Shutterstock.Ĭross-sensitisation between cashew and other tree nuts, such as hazelnut and walnut has been reported at IgE level as well as at T-cell level where mostly Ana o 1 and Ana o 2 acted as cross-reacting allergens. Phylogenetic classification of Anacardiaceae family members in accordance to other tree nuts: almond ( Prunus dulcis), Brazil nut ( Bertholletia excelsa), cashew ( Anacardium accidentale), chestnut (genus Castanea), hazelnut (genus Corylus), macademia (genus Macademia), mango (genus Magnifera), pecan ( Carya illinoinensis), pine nut ( Pinus koraiensis), pink peppercorn ( Schinus terebinthifolia/molle), pistachio ( Pistacia vera), sumac (genus Rhus), and walnut ( Juglans regia). Bet v 1 homologues) and pan allergens (profilin and hevein-related proteins) present in tree nuts and other botanically related foods. The underlying reason is thought to be the major sequential and structural homology between the highly abundant seed storage proteins (glycinins, vicilins, and 2S albumins) and to a lesser extent the defence-related proteins (nsLTP, chitinases, and PR-10 proteins, e.g. ![]() Several studies have shown that a tree nut-allergic patient has considerable chance of being sensitised (86%) or allergic to multiple tree nuts (35–37% based on clinical history and 14–47% based on food challenges ). This raises the question whether cashew nut allergy manifests from a primary sensitisation or is caused by cross-sensitisation to botanically related or unrelated foods.Ĭashew belongs to the family of Anacardiaceae, categorised under the taxonomic class of Magnoliopsida to which most common tree nuts belong, as depicted in Figure Figure1. Often, young children suffer from a cashew nut allergy without a clear history of cashew nut consumption. ![]() Cashew nut allergy has been recognised as a severe tree nut allergy amongst (Dutch) children and young adults, and its prevalence seems to be increasing. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |